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Literature summary for 7.2.2.3 extracted from

  • Libano-Soares, J.D.; Landgraf, S.S.; Gomes-Quintana, E.; Lopes, A.G.; Caruso-Neves, C.
    Prostaglandin E2 modulates proximal tubule Na+-ATPase activity: cooperative effect between protein kinase A and protein kinase C (2011), Arch. Biochem. Biophys., 507, 281-286.
    View publication on PubMed
Search for more literature for 7.2.2.3

Activating Compound

Activating Compound Comment Organism Structure
additional information the addition of 0.001 mM guanosine 5’-O-(2-thiodiphosphate) does not change the enzyme activity Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
Furosemide
-
 Sus scrofa
prostaglandin E2 dose-dependent inhibition with maximal effect at 1 nM. The addition of 0.001 mM prostaglandin E2 decreases Na+-ATPase activity by 41%. The inhibitory effect of prostaglandin E2 on proximal tubule Na+-ATPase activity involves G protein and the activation of protein kinase A. The protein A-mediated inhibitory effect of prostaglandin E2 on Na+-ATPase activity requires previous activation of protein kinase C Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Sus scrofa 16020
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
renal proximal tubule
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in
-
 Sus scrofa ADP + phosphate + Na+/out
-
 ?

Synonyms

Synonyms Comment Organism
Na+-ATPase
-
 Sus scrofa