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Literature summary for 7.2.2.3 extracted from

  • Vives, D.; Farage, S.; Motta, R.; Lopes, A.G.; Caruso-Neves, C.
    Atrial natriuretic peptides and urodilatin modulate proximal tubule Na+-ATPase activity through activation of the NPR-A/cGMP/PKG pathway (2010), Peptides, 31, 903-908.
    View publication on PubMed
Search for more literature for 7.2.2.3

Inhibitors

Inhibitors Comment Organism Structure
atrial natriuretic peptide selectively inhibits the enzyme in basolateral membranes of kidney proximal tubules by activation of guanylyl cyclase activity, which is inhibited by LY83583 Sus scrofa
additional information guanylyl cyclase inhibitor LY83583 alone does not change the enzyme activity Sus scrofa
urodilatin selectively inhibits the enzyme transiently in basolateral membranes of kidney proximal tubules by activation of guanylyl cyclase activity, which is inhibited by LY83583 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Sus scrofa 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in Sus scrofa
-
 ADP + phosphate + Na+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially through preparation of basolateral membranes of kidney proximal tubules Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-
LLC-PK1 cell a proximal tubule cell line Sus scrofa
-
renal tubule basolateral membranes of kidney proximal tubule cells Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000046
-
 enzyme in isolated basolateral membranes of kidney proximal tubules, in presence of urodilatin or atrial natriuretic peptide, pH 7.0, temperature not specified in the publication Sus scrofa
0.0000084
-
 enzyme in isolated basolateral membranes of kidney proximal tubules, pH 7.0, temperature not specified in the publication Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in
-
 Sus scrofa ADP + phosphate + Na+/out
-
 ?

Synonyms

Synonyms Comment Organism
Na+-ATPase
-
 Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Sus scrofa