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Literature summary for 7.2.2.3 extracted from

  • Assaife-Lopes, N.; Wengert, M.; de Sa Pinheiro, A.A.; Leao-Ferreira, L.R.; Caruso-Neves, C.
    Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway (2009), Arch. Biochem. Biophys., 489, 76-81.
    View publication on PubMed
Search for more literature for 7.2.2.3

Inhibitors

Inhibitors Comment Organism Structure
adenosine inhibits independently of the A3 receptor Sus scrofa
Furosemide a Na+-ATPase specific inhibitor Sus scrofa
Inosine inhibits independently of the A3 receptor Sus scrofa
additional information adenine induces inhibition of Na+-ATPase activity Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Sus scrofa 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in Sus scrofa
-
 ADP + phosphate + Na+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from kidney cortex and basolateral membranes of proximal renal tubule cells Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-
renal tubule basolateral membranes of kidney proximal tubule cells Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in
-
 Sus scrofa ADP + phosphate + Na+/out
-
 ?

Synonyms

Synonyms Comment Organism
renal Na+-ATPase
-
 Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Sus scrofa

General Information

General Information Comment Organism
additional information inosine-induced inhibition of Na+-ATPase activity could be involved in the increased renal sodium excretion during short periods of ischemia Sus scrofa