Literature summary for 7.2.2.3 extracted from

de Souza, A.M.; Lara, L.d.a..S.; Previato, J.O.; Lopes, A.G.; Caruso-Neves, C.; da Silva, B.P.; Parente, J.P.
Modulation of sodium pumps by steroidal saponins (2008), Z. Naturforsch. C, 59, 432-436.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(3beta,22alpha,25R)-26-(beta-D-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside	-	Sus scrofa
(3beta,22alpha,25R)-spirostan-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside	-	Sus scrofa
Furosemide	-	Sus scrofa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3	3.2	Na+	in the presence of 0.00001 mM (3beta,22alpha,25R)-spirostan-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside	Sus scrofa
5.8	-	Na+	-	Sus scrofa
56.7	-	Na+	in the presence of 0.00001 mM (3beta,22alpha,25R)-26-(beta-D-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
basolateral plasma membrane	-	Sus scrofa	16323	-

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Na+/in	-	Sus scrofa	ADP + phosphate + Na+/out	-	?

Synonyms

Synonyms	Comment	Organism
Na+-ATPase	-	Sus scrofa

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000001	-	obtained by extrapolation of half maximal inhibition	Sus scrofa	(3beta,22alpha,25R)-spirostan-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside
0.00001	-	obtained by extrapolation of half maximal inhibition	Sus scrofa	(3beta,22alpha,25R)-26-(beta-D-glucopyranosyloxy)-2-methoxyfurost-5-en-3-yl O-D-apio-beta-D-furanosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside

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Release 2023.1 (January 2023)