Literature summary for 7.2.2.3 extracted from

Fujii, T.; Ohira, Y.; Itomi, Y.; Takahashi, Y.; Asano, S.; Morii, M.; Takeguchi, N.; Sakai, H.
Inhibition of P-type ATPases by [(dihydroindenyl)oxy]acetic acid (DIOA), a K+ -Cl- cotransporter inhibitor (2007), Eur. J. Pharmacol., 560, 123-126.

Search for more literature for 7.2.2.3

Application

Application	Comment	Organism
pharmacology	lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells	Sus scrofa
pharmacology	lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells	Canis lupus familiaris

Inhibitors

Inhibitors	Comment	Organism	Structure
Ouabain	-	Canis lupus familiaris
Ouabain	-	Sus scrofa
[(dihydroindenyl)oxy]acetic acid	DIOA	Canis lupus familiaris
[(dihydroindenyl)oxy]acetic acid	DIOA	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Sus scrofa	16020	-

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Canis lupus familiaris	-
LLC-PK1 cell	in the membrane of porcine LLC-PK1 cells stably expressing rabbit gastric H+,K+-ATPase, [(dihydroindenyl)oxy]acetic acid inhibits activities of endogenous Na+,K+-ATPase	Sus scrofa	-

Synonyms

Synonyms	Comment	Organism
Na+,K+-ATPase	-	Sus scrofa
Na+,K+-ATPase	-	Canis lupus familiaris
Na+-exporting ATPase	-	Sus scrofa
Na+-exporting ATPase	-	Canis lupus familiaris
P-type ATPase	-	Sus scrofa
P-type ATPase	-	Canis lupus familiaris

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	Na+,K+-ATPase activity assay	Sus scrofa
37	-	Na+,K+-ATPase activity assay	Canis lupus familiaris

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	Na+,K+-ATPase activity assay	Sus scrofa
7.4	-	Na+,K+-ATPase activity assay	Canis lupus familiaris

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.053	-	-	Canis lupus familiaris	[(dihydroindenyl)oxy]acetic acid
0.095	-	endogenous Na+,K+-ATPase	Sus scrofa	[(dihydroindenyl)oxy]acetic acid

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Release 2023.1 (January 2023)