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Literature summary for 7.2.2.21 extracted from

  • Adle, D.J.; Sinani, D.; Kim, H.; Lee, J.
    A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae (2007), J. Biol. Chem., 282, 947-955.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.21

Cloned(Commentary)

Cloned (Comment) Organism
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 Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
G970R naturally occurring missense mutation presented in a number of yeast laboratory strains, loss of function, mutation is not found in wild type strains Saccharomyces cerevisiae
additional information site-directed mutagenesis of conserved amino acids among P1B-type ATPases, including the CXXC motif (C421, C424), the CPX motif (C859), and the phosphorylation site (Asp-903), completely abolished cadmium resistance Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane G970R mutation affects correct trafficking of the protein Saccharomyces cerevisiae 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cd2+/in Saccharomyces cerevisiae active transport of Cd2+ out of the cell to maintain metal homeostasis ADP + phosphate + Cd2+/out
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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 different laboratory (S288c, BY4741, DTY1, EG103, SKY9, and YPH98) and wild type strains (RM11-1a and Fleischmann’s), PCA1 allele in all laboratory yeast strains examined carries a missense mutation in a conserved residue resulting in loss of function, wild-type PCA1 allele confers cadmium resistance by an Cd2+ efflux mechanism
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cd2+/in active transport of Cd2+ out of the cell to maintain metal homeostasis Saccharomyces cerevisiae ADP + phosphate + Cd2+/out
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 ?

Synonyms

Synonyms Comment Organism
cadmium-transporting P1B-type ATPase
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 Saccharomyces cerevisiae
PCA1
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 Saccharomyces cerevisiae