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Literature summary for 7.2.2.20 extracted from

  • Quan, G.; Xia, P.; Lian, S.; Wu, Y.; Zhu, G.
    Zinc uptake system ZnuACB is essential for maintaining pathogenic phenotype of F4ac+enterotoxigenic E. coli (ETEC) under a zinc restricted environment (2020), Vet. Res., 51, 127.
    View publication on PubMed
Search for more literature for 7.2.2.20

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side 1] Escherichia coli
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 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side 1] Escherichia coli C83902
-
 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 pathogenic phenotype of F4ac+, consisting of three fimbrial variants F4ab, F4ac and F4ad
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Escherichia coli C83902
-
 pathogenic phenotype of F4ac+, consisting of three fimbrial variants F4ab, F4ac and F4ad
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side 1]
-
 Escherichia coli ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side 1]
-
 Escherichia coli C83902 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?

Synonyms

Synonyms Comment Organism
ZnuACB
-
 Escherichia coli

Expression

Organism Comment Expression
Escherichia coli under zinc deficiency conditions, the expression of znuACB is significantly upregulated compared to zinc adequate medium up

General Information

General Information Comment Organism
malfunction the deletion of znuACB genes results in growth perturbation and a sharp decrease in the ability of biofilm formation and adhesion of bacteria in vitro Escherichia coli
physiological function zinc uptake system ZnuACB is essential for maintaining pathogenic phenotype of F4ac+ enterotoxigenic Escherichia coli (ETEC) under a zinc restricted environment. Pathogens utilize high affinity Zn2+ transporters, such as ZnuACB to compete with the host for zinc. It is essential for bacteria to maintain zinc homeostasis and thus maintain their physiology and pathogenesis Escherichia coli