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Literature summary for 7.2.2.20 extracted from

  • Goethe, E.; Gieseke, A.; Laarmann, K.; Lührs, J.; Goethea, R.
    Identification and characterization of mycobacterium smegmatis and mycobacterium avium subsp. paratuberculosis zinc transporters (2021), J. Bacteriol., 203, e00049-21.
    View publication on PubMed
Search for more literature for 7.2.2.20

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side 1] Mycolicibacterium smegmatis
-
 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side 1] Mycobacterium avium subsp. paratuberculosis
-
 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium avium subsp. paratuberculosis
-
-
-
Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side 1]
-
 Mycolicibacterium smegmatis ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side 1]
-
 Mycobacterium avium subsp. paratuberculosis ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?

Synonyms

Synonyms Comment Organism
ZnuABC1
-
 Mycolicibacterium smegmatis
ZnuABC1
-
 Mycobacterium avium subsp. paratuberculosis
ZnuABC2
-
 Mycolicibacterium smegmatis
ZnuABC2
-
 Mycobacterium avium subsp. paratuberculosis

Expression

Organism Comment Expression
Mycolicibacterium smegmatis upon zinc limitation expression of genes encoding ZnuABC is increased up
Mycobacterium avium subsp. paratuberculosis upon zinc limitation expression of genes encoding ZnuABC is increased up

General Information

General Information Comment Organism
malfunction deletion of either ZnuABC1 or ZnuABC2 does not lead to growth defects. Simultaneous deletion of both transporters causes severe growth defects Mycolicibacterium smegmatis
malfunction deletion of either ZnuABC1 or ZnuABC2 does not lead to growth defects. Simultaneous deletion of both transporters causes severe growth defects Mycobacterium avium subsp. paratuberculosis
physiological function ZnuABC is an important zinc importer which is expressed to restore zinc homeostasis when the cytosolic concentration decreases beyond a critical threshold Mycolicibacterium smegmatis
physiological function ZnuABC is an important zinc importer which is expressed to restore zinc homeostasis when the cytosolic concentration decreases beyond a critical threshold Mycobacterium avium subsp. paratuberculosis