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Literature summary for 7.2.2.20 extracted from

  • Meléndez, A.; Valencia, D.; Yukl, E.
    Specificity of interactions between components of two zinc abc transporters in Paracoccus denitrificans (2020), Int. J. Mol. Sci., 21, 1-12.
    View publication on PubMed
Search for more literature for 7.2.2.20

Organism

Organism UniProt Comment Textmining
Paracoccus denitrificans A1B9L0 ZnuA, periplasmic solute binding protein of the zinc ABC transporter ZnuABC
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Paracoccus denitrificans A1B2F3 AztC, periplasmic solute binding protein of the zinc ABC transporter AztABCD
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Paracoccus denitrificans Pd 1222 A1B9L0 ZnuA, periplasmic solute binding protein of the zinc ABC transporter ZnuABC
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Paracoccus denitrificans Pd 1222 A1B2F3 AztC, periplasmic solute binding protein of the zinc ABC transporter AztABCD
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Synonyms

Synonyms Comment Organism
AztABC
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 Paracoccus denitrificans
znuABC
-
 Paracoccus denitrificans

General Information

General Information Comment Organism
drug target as the enzyme is critical for survival in metal-limited environments such as the human host, makes it attractive as potential antibiotic drug target Paracoccus denitrificans
physiological function the enzyme is responsible for the specific uptake of the essential metals zinc, making it necessary for survival in metal-limited environments. In Paracoccus denitrificans, there are two zinc ABC transporter systems: ZnuABC and AztABCD with apparently redundant functions under zinc-limited conditions. Although the AztABCD and ZnuABC systems are redundant under zinc depleted conditions, their respective solute binding proteins (AztC and ZnuA) cannot transfer zinc to the permease of the other system Paracoccus denitrificans