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Literature summary for 7.2.2.20 extracted from

  • Yekwa, E.; Serrano, F.; Yukl, E.
    Conformational flexibility in the zinc solute-binding protein ZnuA (2022), Acta Crystallogr. Sect. F, 78, 128-134.
    View publication on PubMed
Search for more literature for 7.2.2.20

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion method at 25°C Citrobacter koseri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side 1] Citrobacter koseri
-
 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side 1] Citrobacter koseri ATCC BAA-895
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 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Citrobacter koseri A8AFI6 high-affinity zinc uptake system protein ZnuA
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Citrobacter koseri ATCC BAA-895 A8AFI6 high-affinity zinc uptake system protein ZnuA
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side 1]
-
 Citrobacter koseri ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side 1] the enzyme exhibits a different zinc-coordination environment and a closed rather than an open conformation. The flexible conformational landscape may be important for efficient zinc binding and/or delivery to the membrane permease Citrobacter koseri ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side 1]
-
 Citrobacter koseri ATCC BAA-895 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side 1] the enzyme exhibits a different zinc-coordination environment and a closed rather than an open conformation. The flexible conformational landscape may be important for efficient zinc binding and/or delivery to the membrane permease Citrobacter koseri ATCC BAA-895 ADP + phosphate + Zn2+[side 2] + [zinc-binding protein][side 1]
-
 ?

Synonyms

Synonyms Comment Organism
ZnuA
-
 Citrobacter koseri

General Information

General Information Comment Organism
drug target high-affinity zinc uptake system is important for survival and virulence, making them attractive targets for the development of novel antibiotics Citrobacter koseri
physiological function high-affinity zinc uptake system is important for survival and virulence Citrobacter koseri