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Literature summary for 7.2.2.20 extracted from

  • Petrarca, P.; Ammendola, S.; Pasquali, P.; Battistoni, A.
    The Zur-regulated ZinT protein is an auxiliary component of the high-affinity ZnuABC zinc transporter that facilitates metal recruitment during severe zinc shortage (2010), J. Bacteriol., 192, 1553-1564 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.20

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side1] Salmonella enterica
-
 ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side1] Salmonella enterica MA6926
-
 ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
 serovar typhimurium
-
Salmonella enterica MA6926
-
 serovar typhimurium
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Q Sepharose column chromatography Salmonella enterica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side1]
-
 Salmonella enterica ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side1]
-
 Salmonella enterica MA6926 ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?

Synonyms

Synonyms Comment Organism
high-affinity zinc transporter
-
 Salmonella enterica
ZnuA periplasmic component of the zinc transporter Salmonella enterica
znuABC
-
 Salmonella enterica

General Information

General Information Comment Organism
malfunction Salmonella strains producing a modified form of subunit ZnuA which lacks a characteristic histidine-rich domain exhibit a ZinT-dependent capability to import zinc either in vitro or in infected mice Salmonella enterica
physiological function the periplasmic proteins ZinT and ZnuA cooperate in the process of zinc recruitment as they form a stable binary complex in vitro. ZnuA is a protein involved in the frontline response to zinc deficiency, whereas ZinT participates in the bacterial response to more severe zinc deficiency Salmonella enterica