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Literature summary for 7.2.2.20 extracted from

  • Ammendola, S.; Pasquali, P.; Pistoia, C.; Petrucci, P.; Petrarca, P.; Rotilio, G.; Battistoni, A.
    High-affinity Zn2+ uptake system ZnuABC is required for bacterial zinc homeostasis in intracellular environments and contributes to the virulence of Salmonella enterica (2007), Infect. Immun., 75, 5867-5876 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.20

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side1] Salmonella enterica
-
 ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side1] Salmonella enterica ATCC 14028
-
 ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
-
-
Salmonella enterica ATCC 14028
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side1]
-
 Salmonella enterica ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?
ATP + H2O + Zn2+-[zinc-binding protein][side1]
-
 Salmonella enterica ATCC 14028 ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?

Synonyms

Synonyms Comment Organism
high-affinity Zn2+ transporter
-
 Salmonella enterica
znuABC
-
 Salmonella enterica

General Information

General Information Comment Organism
malfunction a deletion mutant of subunit znuA drastically reduces the ability of Salmonella enterica to multiply in media deprived of zinc, impairs its ability to grow in Caco-2 epithelial cells, and lead to decreased ability to multiply in phagocytes under zinc starving conditions Salmonella enterica
physiological function the enzyme contributes to the virulence of Salmonella enterica, is required for Salmonella enterica growth in poor zinc environments, and contributes to Salmonella multiplication within eukaryotic cells and accumulates in intracellular environments Salmonella enterica