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Literature summary for 7.2.2.20 extracted from

  • Gabbianelli, R.; Scotti, R.; Ammendola, S.; Petrarca, P.; Nicolini, L.; Battistoni, A.
    Role of ZnuABC and ZinT in Escherichia coli O157 H7 zinc acquisition and interaction with epithelial cells (2011), BMC Microbiol., 11, 36 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side1] Escherichia coli
-
 ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+-[zinc-binding protein][side1]
-
 Escherichia coli ADP + phosphate + Zn2+[side2] + [zinc-binding protein][side2]
-
 ?

Synonyms

Synonyms Comment Organism
znuABC
-
 Escherichia coli

Expression

Organism Comment Expression
Escherichia coli the expression of subunit znuA, regulated by Zur, is induced in zinc-poor media and in bacteria adhering to cultured epithelial cells up

General Information

General Information Comment Organism
malfunction inactivation of the subunit gene znuA significantly decreases Escherichia coli O157:H7 ability to grow in zinc depleted media. Lack of subunit ZnuA affects the adhesion ability of the bacteria to cultured epithelial cells Escherichia coli
physiological function the transporter plays a critical role in zinc uptake. The periplasmic protein ZinT contributes to the subunit ZnuA-mediated recruitment of zinc in the periplasmic space Escherichia coli