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Literature summary for 7.2.2.2 extracted from

  • Adle, D.J.; Wei, W.; Smith, N.; Bies, J.J.; Lee, J.
    Cadmium-mediated rescue from ER-associated degradation induces expression of its exporter (2009), Proc. Natl. Acad. Sci. USA, 106, 10189-10194.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.2

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum the N terminus of Pca1 contains a targeting signal for ERAD. Degradation of Pca1 and cadmium sensing occur at the endoplasmic reticulum Saccharomyces cerevisiae 5783
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cd2+/in
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 Saccharomyces cerevisiae ADP + phosphate + Cd2+/out
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 ?

Synonyms

Synonyms Comment Organism
PCA1
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 Saccharomyces cerevisiae

Expression

Organism Comment Expression
Saccharomyces cerevisiae in the absence of its cadmium substrate, Pca1 is rapidly degraded through the endoplasmic reticulum-associated degradation pathway down
Saccharomyces cerevisiae endoplasmic reticulum-associated degradation (ERAD) system is responsible for the regulation of Pca1 expression by cadmium. Direct cadmium sensing at the endoplasmic reticulum by a degron in Pca1 leads to an escape of Pca1 from endoplasmic reticulum-associated degradation additional information