Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | N-acetylcysteine, a precursor of glutathione, induces the enzyme expression, restoring the expression in presence of Cd2+ | Saccharomyces cerevisiae |
Cloned (Comment) | Organism |
---|---|
gene YCF1, semiquantitative expression analysis in absence and presence of Cd2+, overview | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | increased accumulation of GSH in the ycf1 deletion strain during respiratory metabolism | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cd2+/in | Saccharomyces cerevisiae | Cd2+ is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione, and thus alter the intracellular redox state. In Saccharomyces cerevisiae, bis(glutathionato)cadmium, Cd-[GS]2, complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p, which plays a role in Cd2+ detoxi?cation during respiratory metabolism and is correlated with the glutathione homeostasis, overview | ADP + phosphate + Cd2+/out | - |
? | |
ATP + H2O + Cd2+/in | Saccharomyces cerevisiae BY4741 | Cd2+ is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione, and thus alter the intracellular redox state. In Saccharomyces cerevisiae, bis(glutathionato)cadmium, Cd-[GS]2, complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p, which plays a role in Cd2+ detoxi?cation during respiratory metabolism and is correlated with the glutathione homeostasis, overview | ADP + phosphate + Cd2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
gene YCF1 | - |
Saccharomyces cerevisiae BY4741 | - |
gene YCF1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cd2+/in | - |
Saccharomyces cerevisiae | ADP + phosphate + Cd2+/out | - |
? | |
ATP + H2O + Cd2+/in | Cd2+ is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione, and thus alter the intracellular redox state. In Saccharomyces cerevisiae, bis(glutathionato)cadmium, Cd-[GS]2, complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p, which plays a role in Cd2+ detoxi?cation during respiratory metabolism and is correlated with the glutathione homeostasis, overview | Saccharomyces cerevisiae | ADP + phosphate + Cd2+/out | - |
? | |
ATP + H2O + Cd2+/in | - |
Saccharomyces cerevisiae BY4741 | ADP + phosphate + Cd2+/out | - |
? | |
ATP + H2O + Cd2+/in | Cd2+ is a toxic environmental contaminant for biological systems, which can form complexes with reduced glutathione, and thus alter the intracellular redox state. In Saccharomyces cerevisiae, bis(glutathionato)cadmium, Cd-[GS]2, complexes can be removed from the cytosol and transported into the vacuole by a glutathione-conjugated pump, Ycf1p, which plays a role in Cd2+ detoxi?cation during respiratory metabolism and is correlated with the glutathione homeostasis, overview | Saccharomyces cerevisiae BY4741 | ADP + phosphate + Cd2+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ycf1p | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Saccharomyces cerevisiae |
Organism | Comment | Expression |
---|---|---|
Saccharomyces cerevisiae | the expression of gene YFC1 is downregulated in presence of Cd2+, which affects the YFC1 promoter | down |