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Literature summary for 7.2.2.19 extracted from
- The gastric HK-ATPase: structure, function, and inhibition (2009), Pflugers Arch., 457, 609-622.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K791S | the mutation greatly reduces enzyme activity as well as increases the Ki for 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | Homo sapiens |
| K791S | the mutation greatly reduces enzyme activity as well as increases the Ki for 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | Rattus norvegicus |
| K791S | the mutation greatly reduces enzyme activity as well as increases the Ki for 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | Oryctolagus cuniculus |
| K791S | the mutation greatly reduces enzyme activity as well as increases the Ki for 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | Canis lupus familiaris |
| K791S | the mutation greatly reduces enzyme activity as well as increases the Ki for SCH28080 | Sus scrofa |
| additional information | mutations towards the exoplasmic surface of TM4, TM5, TM6, the loop between TM5 and TM6, and one site at the end of TM8 altered either the Ki or change the nature of inhibition from strictly competitive to mixed or even non-competitive without affecting ion affinity | Homo sapiens |
| additional information | mutations towards the exoplasmic surface of TM4, TM5, TM6, the loop between TM5 and TM6, and one site at the end of TM8 altered either the Ki or change the nature of inhibition from strictly competitive to mixed or even non-competitive without affecting ion affinity | Rattus norvegicus |
| additional information | mutations towards the exoplasmic surface of TM4, TM5, TM6, the loop between TM5 and TM6, and one site at the end of TM8 altered either the Ki or change the nature of inhibition from strictly competitive to mixed or even non-competitive without affecting ion affinity | Sus scrofa |
| additional information | mutations towards the exoplasmic surface of TM4, TM5, TM6, the loop between TM5 and TM6, and one site at the end of TM8 altered either the Ki or change the nature of inhibition from strictly competitive to mixed or even non-competitive without affecting ion affinity | Oryctolagus cuniculus |
| additional information | mutations towards the exoplasmic surface of TM4, TM5, TM6, the loop between TM5 and TM6, and one site at the end of TM8 altered either the Ki or change the nature of inhibition from strictly competitive to mixed or even non-competitive without affecting ion affinity | Canis lupus familiaris |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | i.e. SCH28080 | Canis lupus familiaris |  |
| 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | i.e. SCH28080 | Homo sapiens | |
| 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | i.e. SCH28080 | Oryctolagus cuniculus | |
| 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | i.e. SCH28080 | Rattus norvegicus | |
| 2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | i.e. SCH28080 | Sus scrofa | |
| BYK36399 | - |
Canis lupus familiaris | |
| BYK36399 | - |
Homo sapiens | |
| BYK36399 | - |
Oryctolagus cuniculus | |
| BYK36399 | - |
Rattus norvegicus | |
| BYK36399 | - |
Sus scrofa | |
| esomeprazole | - |
Canis lupus familiaris | |
| esomeprazole | - |
Homo sapiens | |
| esomeprazole | - |
Oryctolagus cuniculus | |
| esomeprazole | - |
Rattus norvegicus | |
| esomeprazole | - |
Sus scrofa | |
| lansoprazole | - |
Canis lupus familiaris | |
| lansoprazole | - |
Homo sapiens | |
| lansoprazole | - |
Oryctolagus cuniculus | |
| lansoprazole | - |
Rattus norvegicus | |
| lansoprazole | - |
Sus scrofa | |
| additional information | inhibitor binding and inhibition kinetics | Canis lupus familiaris | |
| additional information | inhibitor binding and inhibition kinetics | Homo sapiens | |
| additional information | inhibitor binding and inhibition kinetics | Oryctolagus cuniculus | |
| additional information | inhibitor binding and inhibition kinetics | Rattus norvegicus | |
| additional information | inhibitor binding and inhibition kinetics | Sus scrofa | |
| N-methyl-BYK36399 | - |
Canis lupus familiaris | |
| N-methyl-BYK36399 | - |
Homo sapiens | |
| N-methyl-BYK36399 | - |
Oryctolagus cuniculus | |
| N-methyl-BYK36399 | - |
Rattus norvegicus | |
| N-methyl-BYK36399 | - |
Sus scrofa | |
| Omeprazole | - |
Canis lupus familiaris | |
| Omeprazole | - |
Homo sapiens | |
| Omeprazole | - |
Oryctolagus cuniculus | |
| Omeprazole | - |
Rattus norvegicus | |
| Omeprazole | - |
Sus scrofa | |
| pantoprazole | - |
Canis lupus familiaris | |
| pantoprazole | - |
Homo sapiens | |
| pantoprazole | - |
Oryctolagus cuniculus | |
| pantoprazole | - |
Rattus norvegicus | |
| pantoprazole | - |
Sus scrofa | |
| rabeprazole | - |
Canis lupus familiaris | |
| rabeprazole | - |
Homo sapiens | |
| rabeprazole | - |
Oryctolagus cuniculus | |
| rabeprazole | - |
Rattus norvegicus | |
| rabeprazole | - |
Sus scrofa | |
| timoprazole | - |
Canis lupus familiaris | |
| timoprazole | - |
Homo sapiens | |
| timoprazole | - |
Oryctolagus cuniculus | |
| timoprazole | - |
Rattus norvegicus | |
| timoprazole | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | apical membrane | Sus scrofa | 16020 | - |
| membrane | apical membrane | Oryctolagus cuniculus | 16020 | - |
| membrane | apical membrane | Canis lupus familiaris | 16020 | - |
| membrane | apical membrane, cytoplasmic tubular membranes in the resting state | Homo sapiens | 16020 | - |
| membrane | apical membrane, cytoplasmic tubular membranes in the resting state | Rattus norvegicus | 16020 | - |
| microsome | relatively ion tight vesicles | Sus scrofa | - |
- |
| microvillus | microvilli of the expanded secretory canaliculus in the stimulated state of the parietal cell | Homo sapiens | 5902 | - |
| microvillus | microvilli of the expanded secretory canaliculus in the stimulated state of the parietal cell | Rattus norvegicus | 5902 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens | |
| Mg2+ | required | Rattus norvegicus | |
| Mg2+ | required | Sus scrofa | |
| Mg2+ | required | Oryctolagus cuniculus | |
| Mg2+ | required | Canis lupus familiaris | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + H+/in + K+/out | Homo sapiens | the H,K-ATPase is the final step of acid secretion | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | Rattus norvegicus | the H,K-ATPase is the final step of acid secretion | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | Sus scrofa | the H,K-ATPase is the final step of acid secretion | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | Oryctolagus cuniculus | the H,K-ATPase is the final step of acid secretion | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | Canis lupus familiaris | the H,K-ATPase is the final step of acid secretion | ADP + phosphate + H+/out + K+/in | - |
? | |
| additional information | Homo sapiens | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | ? | - |
? | |
| additional information | Rattus norvegicus | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | ? | - |
? | |
| additional information | Sus scrofa | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | ? | - |
? | |
| additional information | Oryctolagus cuniculus | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | ? | - |
? | |
| additional information | Canis lupus familiaris | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | N-glycosylation of the beta subunit | Homo sapiens |
| glycoprotein | N-glycosylation of the beta subunit | Rattus norvegicus |
| glycoprotein | N-glycosylation of the beta subunit | Sus scrofa |
| glycoprotein | N-glycosylation of the beta subunit | Oryctolagus cuniculus |
| glycoprotein | N-glycosylation of the beta subunit | Canis lupus familiaris |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] | orientation of the subunits in the membrane towards cytoplasmic and periplasmic sides and reaction mechanism, detailed overview | Homo sapiens | |
| ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] | orientation of the subunits in the membrane towards cytoplasmic and periplasmic sides and reaction mechanism, detailed overview | Rattus norvegicus | |
| ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] | orientation of the subunits in the membrane towards cytoplasmic and periplasmic sides and reaction mechanism, detailed overview | Sus scrofa | |
| ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] | orientation of the subunits in the membrane towards cytoplasmic and periplasmic sides and reaction mechanism, detailed overview | Oryctolagus cuniculus | |
| ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] | orientation of the subunits in the membrane towards cytoplasmic and periplasmic sides and reaction mechanism, detailed overview | Canis lupus familiaris |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| oxyntic cell | - |
Homo sapiens | - |
| oxyntic cell | - |
Rattus norvegicus | - |
| oxyntic cell | - |
Sus scrofa | - |
| oxyntic cell | - |
Oryctolagus cuniculus | - |
| oxyntic cell | - |
Canis lupus familiaris | - |
| renal medulla | - |
Homo sapiens | - |
| renal medulla | - |
Rattus norvegicus | - |
| renal medulla | - |
Sus scrofa | - |
| renal medulla | - |
Oryctolagus cuniculus | - |
| renal medulla | - |
Canis lupus familiaris | - |
| stomach | - |
Homo sapiens | - |
| stomach | - |
Rattus norvegicus | - |
| stomach | - |
Sus scrofa | - |
| stomach | - |
Oryctolagus cuniculus | - |
| stomach | - |
Canis lupus familiaris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + H+/in + K+/out | - |
Homo sapiens | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | - |
Rattus norvegicus | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | - |
Sus scrofa | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | - |
Oryctolagus cuniculus | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | - |
Canis lupus familiaris | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | the H,K-ATPase is the final step of acid secretion | Homo sapiens | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | the H,K-ATPase is the final step of acid secretion | Rattus norvegicus | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | the H,K-ATPase is the final step of acid secretion | Sus scrofa | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | the H,K-ATPase is the final step of acid secretion | Oryctolagus cuniculus | ADP + phosphate + H+/out + K+/in | - |
? | |
| ATP + H2O + H+/in + K+/out | the H,K-ATPase is the final step of acid secretion | Canis lupus familiaris | ADP + phosphate + H+/out + K+/in | - |
? | |
| additional information | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | Homo sapiens | ? | - |
? | |
| additional information | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | Rattus norvegicus | ? | - |
? | |
| additional information | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | Sus scrofa | ? | - |
? | |
| additional information | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | Oryctolagus cuniculus | ? | - |
? | |
| additional information | a K+ efflux channel is associated with the gastric H,K-ATPase, KCNQ1-KCNE2 appears to be the K+ efflux channel that is essential for gastric acid secretion | Canis lupus familiaris | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | alphabeta structure, determination of the primary structure of the gastric H,K-ATPase alpha subunit containing the catalytic site, sequence comparison | Homo sapiens |
| heterodimer | alphabeta structure, determination of the primary structure of the gastric H,K-ATPase alpha subunit containing the catalytic site, sequence comparison | Rattus norvegicus |
| heterodimer | alphabeta structure, determination of the primary structure of the gastric H,K-ATPase alpha subunit containing the catalytic site, sequence comparison | Sus scrofa |
| heterodimer | alphabeta structure, determination of the primary structure of the gastric H,K-ATPase alpha subunit containing the catalytic site, sequence comparison | Oryctolagus cuniculus |
| heterodimer | alphabeta structure, determination of the primary structure of the gastric H,K-ATPase alpha subunit containing the catalytic site, sequence comparison | Canis lupus familiaris |
| More | a cluster of intramembranal carboxylic amino acids is located in the middle of the transmembrane segments TM4, TM5,TM6, and TM8 of the alpha-subunit that contains the ion binding domain in this enzyme and the ATPase | Homo sapiens |
| More | a cluster of intramembranal carboxylic amino acids is located in the middle of the transmembrane segments TM4, TM5,TM6, and TM8 of the alpha-subunit that contains the ion binding domain in this enzyme and the ATPase | Rattus norvegicus |
| More | a cluster of intramembranal carboxylic amino acids is located in the middle of the transmembrane segments TM4, TM5,TM6, and TM8 of the alpha-subunit that contains the ion binding domain in this enzyme and the ATPase | Sus scrofa |
| More | a cluster of intramembranal carboxylic amino acids is located in the middle of the transmembrane segments TM4, TM5,TM6, and TM8 of the alpha-subunit that contains the ion binding domain in this enzyme and the ATPase | Oryctolagus cuniculus |
| More | a cluster of intramembranal carboxylic amino acids is located in the middle of the transmembrane segments TM4, TM5,TM6, and TM8 of the alpha-subunit that contains the ion binding domain in this enzyme and the ATPase | Canis lupus familiaris |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gastric HK-ATPase | - |
Homo sapiens |
| gastric HK-ATPase | - |
Rattus norvegicus |
| gastric HK-ATPase | - |
Sus scrofa |
| gastric HK-ATPase | - |
Oryctolagus cuniculus |
| gastric HK-ATPase | - |
Canis lupus familiaris |
| More | the enzyme is a member of the P2-type ATPase family | Homo sapiens |
| More | the enzyme is a member of the P2-type ATPase family | Rattus norvegicus |
| More | the enzyme is a member of the P2-type ATPase family | Sus scrofa |
| More | the enzyme is a member of the P2-type ATPase family | Oryctolagus cuniculus |
| More | the enzyme is a member of the P2-type ATPase family | Canis lupus familiaris |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
| ATP | - |
Sus scrofa | |
| ATP | - |
Oryctolagus cuniculus | |
| ATP | - |
Canis lupus familiaris | |
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