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Literature summary for 7.2.2.19 extracted from

  • Nandi, J.; Das, P.K.; Zinkievich, J.M.; Baltodano, J.D.; Levine, R.A.
    Cyclo-oxygenase-1 inhibition increases acid secretion by modulating H+,K+-ATPase expression and activation in rabbit parietal cells (2009), Clin. Exp. Pharmacol. Physiol., 36, 127-134.
    View publication on PubMed
Search for more literature for 7.2.2.19

Activating Compound

Activating Compound Comment Organism Structure
indomethacin activates by 65% Oryctolagus cuniculus
additional information no activation by DFU, i.e. 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2-(5H)-furanone Oryctolagus cuniculus
SC-560 i.e. 5-(4-chlorophenyl)-1-(4-methyoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole, activates by 61% Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
diclofenac
-
 Oryctolagus cuniculus
piroxicam
-
 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Oryctolagus cuniculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in + K+/out Oryctolagus cuniculus the enzyme is involved in acid secretion in gastric mucosa ADP + phosphate + H+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by purification of plama membranes from parietal cells Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
 Oryctolagus cuniculus
-
oxyntic cell
-
 Oryctolagus cuniculus
-
stomach
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in + K+/out
-
 Oryctolagus cuniculus ADP + phosphate + H+/out + K+/in
-
 ?
ATP + H2O + H+/in + K+/out the enzyme is involved in acid secretion in gastric mucosa Oryctolagus cuniculus ADP + phosphate + H+/out + K+/in
-
 ?

Subunits

Subunits Comment Organism
More the enzyme consists of an alpha and a beta subunit Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
H+/K+-ATPase
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus