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Literature summary for 7.2.2.19 extracted from

  • Yu, Z.; Li, M.; Zhang, D.; Xu, W.; Kone, B.C.
    Sp1 trans-activates the murine H+-K+-ATPase {alpha}2 subunit gene (2009), Am. J. Physiol. Renal Physiol., 297, 63-70.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.19

Activating Compound

Activating Compound Comment Organism Structure
additional information Sp1 protein, a member of the Sp/Krüppel-like factor transcription factors. Sp1, but not Sp3, binds to this promoter region of the HKalpha2 gene in mIMCD3 cells in vivo and transactivates the gene expression. siRNA knockdown of Sp1 inhibits endogenous HKalpha2 mRNA expression Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene HKalpha2, the -144/-135 element is important for HKalpha2 promoter activity, regulation of gene expression and interaction with Sp1 protein, expression analysis, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in + K+/out Mus musculus the H+/K+-ATPase alpha2 gene of renal collecting duct and distal colon plays a central role in potassium and acid-base homeostasis, regulation, overview. Sp1 plays an important and positive role in controlling basal HKalpha2 gene expression in mIMCD3 cells in vivo and in vitro ADP + phosphate + H+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
collecting duct
-
 Mus musculus
-
colon distal Mus musculus
-
epithelial cell
-
 Mus musculus
-
mIMCD-3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in + K+/out
-
 Mus musculus ADP + phosphate + H+/out + K+/in
-
 ?
ATP + H2O + H+/in + K+/out the H+/K+-ATPase alpha2 gene of renal collecting duct and distal colon plays a central role in potassium and acid-base homeostasis, regulation, overview. Sp1 plays an important and positive role in controlling basal HKalpha2 gene expression in mIMCD3 cells in vivo and in vitro Mus musculus ADP + phosphate + H+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
H+-K+-ATPase alpha2
-
 Mus musculus
HKalpha2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus