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Literature summary for 7.2.2.19 extracted from

  • Aw, S.; Adams, D.S.; Qiu, D.; Levin, M.
    H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry (2008), Mech. Dev., 125, 353-372.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.19

Protein Variants

Protein Variants Comment Organism
additional information a LacZ fusion enzyme fused to motor proteins reveals endogenous polarity in the cytoplasmic transport machinery, overview Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
additional information H+/K+-ATPase inhibition does not affect Cx43 expression in chicken Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoskeleton H+/K+-ATPase localization along two axes is dependent on intracellular transport machinery, overview Gallus gallus 5856
-
cytoskeleton H+/K+-ATPase localization along two axes is dependent on intracellular transport machinery, overview Xenopus laevis 5856
-
membrane
-
 Gallus gallus 16020
-
membrane
-
 Xenopus laevis 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in + K+/out Xenopus laevis the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview ADP + phosphate + H+/out + K+/in
-
 ?
ATP + H2O + H+/in + K+/out Gallus gallus the known requirement for H+/K+-ATPase function in chick asymmetry does not function through effects on the circumferential expression pattern of Connexin43, physiological function, overview ADP + phosphate + H+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Xenopus laevis
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] mechanistic modeling of the physiological events linking subcellular processes to largescale patterning involving the enzyme Gallus gallus
a
ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1] mechanistic modeling of the physiological events linking subcellular processes to largescale patterning involving the enzyme Xenopus laevis
a

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Xenopus laevis
-
embryo H+/K+-ATPase and Kir4.1 are expressed in the primitive streak Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in + K+/out
-
 Gallus gallus ADP + phosphate + H+/out + K+/in
-
 ?
ATP + H2O + H+/in + K+/out
-
 Xenopus laevis ADP + phosphate + H+/out + K+/in
-
 ?
ATP + H2O + H+/in + K+/out the Kir4.1 potassium channel, while symmetrically expressed in a dynamic fashion during early cleavages, is required for normal LR asymmetry of frog embryos. Thus, Kir4.1 is an ideal candidate for the K+ ion exit path needed to allow the electroneutral H+/K+-ATPase to generate voltage gradients, overview Xenopus laevis ADP + phosphate + H+/out + K+/in
-
 ?
ATP + H2O + H+/in + K+/out the known requirement for H+/K+-ATPase function in chick asymmetry does not function through effects on the circumferential expression pattern of Connexin43, physiological function, overview Gallus gallus ADP + phosphate + H+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
electroneutral H+/K+-ATPase
-
 Gallus gallus
electroneutral H+/K+-ATPase
-
 Xenopus laevis
H+/K+-ATPase
-
 Gallus gallus
H+/K+-ATPase
-
 Xenopus laevis
H,K-ATPase
-
 Gallus gallus
H,K-ATPase
-
 Xenopus laevis