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Literature summary for 7.2.2.19 extracted from

  • Fujii, T.; Ohira, Y.; Itomi, Y.; Takahashi, Y.; Asano, S.; Morii, M.; Takeguchi, N.; Sakai, H.
    Inhibition of P-type ATPases by [(dihydroindenyl)oxy]acetic acid (DIOA), a K+ -Cl- cotransporter inhibitor (2007), Eur. J. Pharmacol., 560, 123-126.
    View publication on PubMed
Search for more literature for 7.2.2.19

Application

Application Comment Organism
pharmacology lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
[(dihydroindenyl)oxy]acetic acid DIOA Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane gastric vesicles are prepared from mucosa in the fundic region of hog stomaches Sus scrofa 16020
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
 Sus scrofa
-
LLC-PK1 cell LLC-PK1 cells stably expressing alpha- and beta subunits of the gatric H+,K+-ATPase Sus scrofa
-

Synonyms

Synonyms Comment Organism
gastric H+,K+-ATPase
-
 Sus scrofa
H+,K+-ATPase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 H+,K+-ATPase activity assay Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 H+,K+-ATPase activity assay Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.097
-
 endogenous Na+,K+-ATPase Sus scrofa [(dihydroindenyl)oxy]acetic acid