Literature summary for 7.2.2.19 extracted from

Lerner, M.; Lemke, D.; Bertram, H.; Schillers, H.; Oberleithner, H.; Caplan, M.J.; Reinhardt, J.
An extracellular loop of the human non-gastric H,K-ATPase a-subunit is involved in apical plasma membrane polarization (2006), Cell. Physiol. Biochem., 18, 75-84.

Search for more literature for 7.2.2.19

Application

Application	Comment	Organism
additional information	the non-gastric H,K-ATPase contains similar sorting motifs in close proximity to the 4th transmembrane spanning domain than the gastric H,K-ATPase, short extracellular loop between the third and the 4th transmembrane spanning domain is critical for the pump´s apical delivery	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression of several chimeras between ATP1AL1 and the Na,K-ATPase in MDCK cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	point mutations of chimeras, single point mutation between the third and 4th transmembrane spanning domain redirects the enzyme to the basolateral membrane	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P54707	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
ATP1al1	-	Homo sapiens
non-gastric H,K-ATPase	-	Homo sapiens

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Release 2023.1 (January 2023)