Literature summary for 7.2.2.19 extracted from

Modyanov, N.; Pestov, N.; Adams, G.; Crambert, G.; Tillekeratne, M.; Zhao, H.; Korneenko, T.; Shakhparonov, M.; Geering, K.
Nongastric H,K-ATPase: structure and functional properties (2003), Ann. N. Y. Acad. Sci., 986, 183-187.

Search for more literature for 7.2.2.19

Inhibitors

Inhibitors	Comment	Organism	Structure
bufalin	-	Homo sapiens
digitoxin	-	Homo sapiens
digoxin	-	Homo sapiens
additional information	almost resistant to digoxigenin and ouabagenin	Homo sapiens
proscillaridin A	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + H+/in + K+/out	the enzyme can function as Na/K exchanger	Homo sapiens	ADP + phosphate + H+/out + K+/in	-	?

Subunits

Subunits	Comment	Organism
More	beta1 is not only a subunit of the Na,K-ATPase, but also serves as an authenthic subunit of nongastric H,K-ATPase	Homo sapiens

Synonyms

Synonyms	Comment	Organism
nongastric H,K-ATPase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	Ki-values of about 0.001 mM: bufalin, proscillaridin A. Digoxin and digitoxin show Ki-values of about 0.01 mM on ATPase reaction and of about 0.005 mM on phosphatase activity	Homo sapiens

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Release 2023.1 (January 2023)