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Literature summary for 7.2.2.14 extracted from

  • Piskacek, M.; Zotova, L.; Zsurka, G.; Schweyen, R.J.
    Conditional knock-down of hMRS2 results in loss of mitochondrial Mg2+ uptake and cell death (2009), J. Cell. Mol. Med., 13, 693-700.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information conditional knock-down of MRS2 by stable long-term expression of specific shRNA in HEK-293 cells results in loss of mitochondrial Mg2+ uptake and cell death, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane Mrs2 is the major transport protein for Mg2+ uptake into mitochondria Homo sapiens 31966
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Mg2+/out Homo sapiens Mrs2 is the major transport protein for Mg2+ uptake into mitochondria, and expression of Mrs2 is essential for the maintenance of respiratory complex I and cell viability ADP + phosphate + Mg2+/in
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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gene gene MRS2L
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Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by mitochondria preparation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
determination of membrane potential of wild-type and transformed HEK-293 cell mitochondria, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Mg2+/out
-
Homo sapiens ADP + phosphate + Mg2+/in
-
?
ATP + H2O + Mg2+/out Mrs2 is the major transport protein for Mg2+ uptake into mitochondria, and expression of Mrs2 is essential for the maintenance of respiratory complex I and cell viability Homo sapiens ADP + phosphate + Mg2+/in
-
?

Synonyms

Synonyms Comment Organism
Mrs2p
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens