Protein Variants | Comment | Organism |
---|---|---|
additional information | conditional knock-down of MRS2 by stable long-term expression of specific shRNA in HEK-293 cells results in loss of mitochondrial Mg2+ uptake and cell death, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | Mrs2 is the major transport protein for Mg2+ uptake into mitochondria | Homo sapiens | 31966 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Mg2+/out | Homo sapiens | Mrs2 is the major transport protein for Mg2+ uptake into mitochondria, and expression of Mrs2 is essential for the maintenance of respiratory complex I and cell viability | ADP + phosphate + Mg2+/in | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene gene MRS2L | - |
Purification (Comment) | Organism |
---|---|
native enzyme partially by mitochondria preparation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
determination of membrane potential of wild-type and transformed HEK-293 cell mitochondria, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Mg2+/out | - |
Homo sapiens | ADP + phosphate + Mg2+/in | - |
? | |
ATP + H2O + Mg2+/out | Mrs2 is the major transport protein for Mg2+ uptake into mitochondria, and expression of Mrs2 is essential for the maintenance of respiratory complex I and cell viability | Homo sapiens | ADP + phosphate + Mg2+/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Mrs2p | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |