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Literature summary for 7.2.2.13 extracted from

  • de Juan-Sanz, J.; Nunez, E.; Villarejo-Lopez, L.; Perez-Hernandez, D.; Rodriguez-Fraticelli, A.E.; Lopez-Corcuera, B.; Vazquez, J.; Aragon, C.
    Na+/K+-ATPase is a new interacting partner for the neuronal glycine transporter GlyT2 that downregulates its expression in vitro and in vivo (2013), J. Neurosci., 33, 14269-14281.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Ouabain 55% inhibition at 0.02 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Rattus norvegicus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
 Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Rattus norvegicus ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na+/K+-ATPase
-
 Rattus norvegicus
NKA
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the neuronal glycine transporter GlyT2 function is strictly coupled to the sodium electrochemical gradient actively generated by the Na/K-ATPase Rattus norvegicus