Literature summary for 7.2.2.13 extracted from

Tipsmark, C.K.; Breves, J.P.; Seale, A.P.; Lerner, D.T.; Hirano, T.; Grau, E.G.
Switching of Na+, K+-ATPase isoforms by salinity and prolactin in the gill of a cichlid fish (2011), J. Endocrinol., 209, 237-244.

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Organism

Organism	UniProt	Comment	Textmining
Oreochromis mossambicus	Q9YH26	subunit alpha-1b	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
gill	-	Oreochromis mossambicus	-

Expression

Organism	Comment	Expression
Oreochromis mossambicus	expression of Na+, K+-ATPase alpha-subunit isoforms alpha-1a and alpha-1b in relationship with salinity acclimation. Transfer of freshwater acclimated fish to seawater results in a marked reduction in alpha-1a expression within 24 h and a significant increase in alpha-1b expression with maximum levels attained 7 days after the transfer. Transfer of seawater-acclimated fish to freshwater induces a marked increase in alpha-1a expression within 2 days, while alpha-1b expression decreases significantly after 14 days. Hypophysectomy results in a virtual shutdown of alpha-1a mRNA expression in both freshwater- and seawtaer-acclimated fish, whereas no significant effect is observed in alpha-1b expression. Replacement therapy by ovine prolactin fully restores alpha-1a expression in freshwater-acclimated fish, while cortisol has a modest, but significant, stimulatory effect on alpha-1a expression. The mRNA expression of fxyd-11, a regulatory Na+,K+-ATPase subunit,is transiently enhanced during both freshwater and seawater acclimation	additional information

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Release 2023.1 (January 2023)