Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Xenopus laevis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Xenopus laevis | - |
General Information | Comment | Organism |
---|---|---|
physiological function | Klotho is a transmembrane protein with particularly strong expression in kidney, parathyroid glands and choroid plexus. Expression of Klotho in Xenopus oocytes increases the Na+/K+ ATPase pump current. Treatment of Xenopus oocytes with Klotho protein similarly increases the pump current | Xenopus laevis |
physiological function | Klotho is a transmembrane protein with particularly strong expression in kidney, parathyroid glands and choroid plexus. Klotho-hypomorphic mice suffer from renal salt wasting and hypovolemia despite hyperaldosteronism. Na+/K+ ATPase protein abundance in isolated collecting ducts is lower in Klothohm mice than in their wild type littermates | Mus musculus |