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Literature summary for 7.2.2.13 extracted from

  • Bruening, C.A.; Prigol, M.; Barancelli, D.A.; Nogueira, C.W.; Zeni, G.
    Disubstituted diaryl diselenides inhibit delta-ALA-D and Na+, K+-ATPase activities in rat brain homogenates in vitro (2009), Mol. Cell. Biochem., 332, 17-24.
    View publication on PubMed
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
diphenyl diselenide activity is restored by DTT Rattus norvegicus
m-trifluoromethyl-diphenyl diselenide i.e. (m-CF3–C6H4Se)2, activity is restored by DTT Rattus norvegicus
p-chloro-diphenyl diselenide i.e. (p-Cl–C6H4Se)2, activity is restored by DTT Rattus norvegicus
p-methoxyl-diphenyl diselenide i.e. (p-CH3O–C6H4Se)2, activity is restored by DTT Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Rattus norvegicus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male adult Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Rattus norvegicus ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na+, K+-ATPase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.006
-
 pH 7.4, 37°C Rattus norvegicus m-trifluoromethyl-diphenyl diselenide
0.006
-
 pH 7.4, 37°C Rattus norvegicus p-chloro-diphenyl diselenide
0.031
-
 pH 7.4, 37°C Rattus norvegicus diphenyl diselenide
0.045
-
 pH 7.4, 37°C Rattus norvegicus p-methoxyl-diphenyl diselenide

General Information

General Information Comment Organism
physiological function inactivation of Na+, K+-ATPase leads to partial membrane depolarization allowing excessive Ca2+ entry inside neurons with resultant toxic events such as excitotoxicity Rattus norvegicus