Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of alpha3 isoform expression by alpha3 siRNA, and increasing alpha1 isoform expression by transient transfection of alpha1 cDNA in Panc-1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
oleandrin | oleandrin treatment results in selective inhibition of human cancer cell growth but not rodent cell proliferation, which corresponds to the relative level of Na,K-ATPase alpha3 subunit protein expression. A correlation is observed between the ratio of alpha3 to alpha1 isoforms and the level of oleandrin uptake during inhibition of cell growth and initiation of cell death, the higher the alpha3 expression relative to alpha1 expression, the more sensitive the cell is to treatment with oleandrin | Homo sapiens | |
oleandrin | oleandrin treatment results in selective inhibition of human cancer cell growth but not rodent cell proliferation, which corresponds to the relative level of Na,K-ATPase alpha3 subunit protein expression. A correlation is observed between the ratio of alpha3 to alpha1 isoforms and the level of oleandrin uptake during inhibition of cell growth and initiation of cell death, the higher the alpha3 expression relative to alpha1 expression, the more sensitive the cell is to treatment with oleandrin | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | - |
Homo sapiens | - |
carcinoma cell | rodent cancer cells lack discernable expression of the alpha3 subunit Na,K-ATPase isoform | Mus musculus | - |
additional information | expression analysis of isozymes alpha1 and alpha3 | Mus musculus | - |
additional information | expression analysis of isozymes alpha1 and alpha3 | Homo sapiens | - |
Panc-02 cell | a pancreatic cancer cell line | Mus musculus | - |
PANC-1 cell | a pancreatic cancer cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Na,K-ATPase | - |
Mus musculus |
Na,K-ATPase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | inhibition of proliferation of Panc-1 cells by oleandrin is significantly reduced when the relative expression of subunit alpha3 is decreased or when the expression of the alpha1 isoform is increased | Homo sapiens |