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Literature summary for 7.2.2.13 extracted from

  • Perez-Gomez, A.; Novelli, A.; Fernandez-Sanchez, M.T.
    Na+/K+-ATPase inhibitor palytoxin enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-dependent mechanisms (2010), J. Neurochem., 114, 28-38.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
palytoxin mild, non-toxic, exposures to the Na+/K+-ATPase inhibitor palytoxin synergistically sensitizes the vulnerability of neurons to normally non-toxic concentrations of domoic acid, leaving NMDA receptor-mediated excitotoxic response unaltered. Palytoxin causes a voltage-sensitive Na+ channel-independent increase in intracellular Na+. Enhancement of the excitotoxic response to domoic acid by palytoxin is time-dependent and is not affected by gene expression inhibitors Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
 Rattus norvegicus
-
neuron cerebellar Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
Na+/K+-ATPase
-
 Rattus norvegicus

General Information

General Information Comment Organism
additional information crucial role for Na+/K+-ATPase activity in determining neuronal vulnerability to domoic acid-mediated excitotoxicity. The enzyme inhibitor palytoxin enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-dependent mechanisms, overview Rattus norvegicus