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Literature summary for 7.2.2.13 extracted from

  • Potter, T.; Hauck, C.; Pocas, E.S.; Diedrichs, H.; Adam, C.; Reuter, H.; Wittwer, T.; Wahlers, T.; da Silva, A.J.; Costa, P.R.; Noel, F.; Mueller-Ehmsen, J.
    Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium - novel aspects of cardiac glycoside pharmacology (2009), J. Cardiovasc. Pharmacol., 54, 10-15.
    View publication on PubMed
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
8-methoxycoumestrol inhibits the isozyme alpha1beta1 Na,K-ATPase, mechanism, overview Homo sapiens
beta-acetyldigoxin
-
 Homo sapiens
digitoxin
-
 Homo sapiens
digoxin
-
 Homo sapiens
methyldigoxin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Homo sapiens
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 three Na,K-ATPase isozymes, alpha1beta1, alpha2beta1, and alpha3beta1
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney isozyme alpha1beta1 Na,K-ATPase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Homo sapiens ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na, K-ATPase
-
 Homo sapiens
Na,K-ATPase
-
 Homo sapiens
NKA
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00009
-
 isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C Homo sapiens 8-methoxycoumestrol
0.000282
-
 isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C Homo sapiens methyldigoxin
0.000287
-
 isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C Homo sapiens digitoxin
0.000409
-
 isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C Homo sapiens digoxin
0.000587
-
 isozyme alpha1beta1 Na,K-ATPase, pH 7.4, 30°C Homo sapiens beta-acetyldigoxin