Any feedback?
Literature summary for 7.2.2.13 extracted from
- Inhibition of glucocorticoid-induced changes of Na+, K+-ATPase in rat lens by a glucocorticoid receptor antagonist RU486 (2010), Exp. Eye Res., 91, 544-549.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lens | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Na+, K+-ATPase | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | dexamethasone and other glucocorticoids inhibit the Na+,K+-ATPase expression in the lens. Glucocorticoid-antagonist RU486 inhibits the decrease of the expression of Na+, K+-ATPase alpha1 subunit induced by dexamethasone | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Na+, K+-ATPase plays a role in regulating electrolyte concentration in the lens, contributing to lens transparency, and is involved in cataract formation caused by prolonged use of glucocorticoids, that suppress the Na+,K+-ATPase in the lens, overview | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
