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Literature summary for 7.2.2.13 extracted from

  • Kimura, T.; Allen, P.B.; Nairn, A.C.; Caplan, M.J.
    Arrestins and spinophilin competitively regulate Na+,K+-ATPase trafficking through association with a large cytoplasmic loop of the Na+,K+-ATPase (2007), Mol. Biol. Cell, 18, 4508-4518.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cells and LLC-PK1 cells Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein enzyme is phopsphorylated by G-protein-coupled receptor kinase in vitro on its large cytoplasmic loop Rattus norvegicus

Subunits

Subunits Comment Organism
More enzyme directly associates with arrestin 2 and 3, G-protein-coupled receptor kinase 2 and 3, protein 14-3-3 epsilon, and spinophilin. Presence of spinophilin blocks the association with arrestin 2 and 3, G-protein-coupled receptor kinase 2 and 3, and protein 14-3-3 epsilon. In COS cells overexpressing arrestin, the Na+K+ATPase is redistributed to intracellular compartments Rattus norvegicus