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Literature summary for 7.2.2.13 extracted from

  • Billimoria, F.R.; Dave, B.N.; Katyare, S.S.
    Neonatal hypothyroidism alters the kinetic properties of Na+, K+-ATPase in synaptic plasma membranes from rat brain (2006), Brain Res. Bull., 70, 55-61.
    View publication on PubMed
Search for more literature for 7.2.2.13

Application

Application Comment Organism
medicine neonatal hypothyroidism results in a generalized decrease in Vmax with ATP, Na+, K+ and Mg2+ together with an increase in the Km value for ATP, appearance of a low affinity component for Na+ and allosteric characteristic for the Mg2+-dependent activity at high concentrations of Mg2+ Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 ATP pH 7.4, 37°C, control Rattus norvegicus
0.11
-
 ATP pH 7.4, 37°C, neonatal hypothyroidism Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Rattus norvegicus 5886
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 with induced neonatal hypothyroidism
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 decrease in specific activity by 78.5% in neonatal hypothyroidism Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in
-
 Rattus norvegicus ADP + phosphate + Na+/out
-
 ?