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Literature summary for 7.2.2.13 extracted from

  • Feldmann, T.; Glukmann, V.; Medvenev, E.; Shpolansky, U.; Galili, D.; Lichtstein, D.; Rosen, H.
    Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis (2007), Am. J. Physiol. Cell Physiol., 293, C885-C896.
    View publication on PubMed
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
bufalin inhibition of the enzyme, enhancement of the acidification of the late endosome, alteration in membrane traffic Homo sapiens
Ouabain inhibition of enzyme, enhancement of the acidification of the late endosome Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome enzyme is involved in endosomal pH regulation Homo sapiens 5768
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Na+K+-ATPase actively participates in the regulation of endosomal pH value and endocytosed membrane traffic ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NTERA-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Na+K+-ATPase actively participates in the regulation of endosomal pH value and endocytosed membrane traffic Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
-
 Homo sapiens Ouabain
0.003
-
-
 Homo sapiens bufalin