BRENDA - Enzyme Database
show all sequences of 7.2.2.13

Na-K-ATPase in rat cerebellar granule cells is redox sensitive

Petrushanko, I.; Bogdanov, N.; Bulygina, E.; Grenacher, B.; Leinsoo, T.; Boldyrev, A.; Gassmann, M.; Bogdanova, A.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R916-925 (2006)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
1-chloro-2,4-dinitrobenzene
increase of the hydrolytic activity of the Na/K ATPase
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
1-chloro-2,4-dinitrobenzene
inhibition of the transport activity of the Na-K pump
Rattus norvegicus
ethylester of glutathione
inhibition of the transport activity of the Na-K pump
Rattus norvegicus
Ouabain
-
Rattus norvegicus
reduced glutathione
extracellular and, or intracellular, inhibition of the transport activity of the Na-K pump
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Rattus norvegicus
16020
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ADP + phosphate + Na+/out
Rattus norvegicus
-
ATP + H2O + Na+/in
-
-
?
ATP + H2O + K+/in
Rattus norvegicus
-
ADP + phosphate + K+/out
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cerebellum
cerebellar granule cells
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
ADP + phosphate + Na+/out
-
671274
Rattus norvegicus
ATP + H2O + Na+/in
-
-
-
?
ATP + H2O + K+/in
-
671274
Rattus norvegicus
ADP + phosphate + K+/out
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
Na-K-ATPase
-
Rattus norvegicus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay condition
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay condition
Rattus norvegicus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
1-chloro-2,4-dinitrobenzene
increase of the hydrolytic activity of the Na/K ATPase
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1-chloro-2,4-dinitrobenzene
inhibition of the transport activity of the Na-K pump
Rattus norvegicus
ethylester of glutathione
inhibition of the transport activity of the Na-K pump
Rattus norvegicus
Ouabain
-
Rattus norvegicus
reduced glutathione
extracellular and, or intracellular, inhibition of the transport activity of the Na-K pump
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Rattus norvegicus
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ADP + phosphate + Na+/out
Rattus norvegicus
-
ATP + H2O + Na+/in
-
-
?
ATP + H2O + K+/in
Rattus norvegicus
-
ADP + phosphate + K+/out
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cerebellum
cerebellar granule cells
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
ADP + phosphate + Na+/out
-
671274
Rattus norvegicus
ATP + H2O + Na+/in
-
-
-
?
ATP + H2O + K+/in
-
671274
Rattus norvegicus
ADP + phosphate + K+/out
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay condition
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay condition
Rattus norvegicus
Other publictions for EC 7.2.2.13
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)