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Literature summary for 7.2.2.13 extracted from
- Lys691 and Asp714 of the Na+/K+-ATPase a subunit are essential for phosphorylation, dephosphorylation, and enzyme turnover (2004), Biochemistry, 43, 4731-4740.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of subunit alpha 1 in Saccharomyces cerevisiae together with dog subunit beta1 | Ovis aries |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D714A | insensitive to palytoxin | Ovis aries |
| D714E | the IC50 of the palytoxin-induced K+ efflux is 4fold higher than in cells expressing the wild-type enzyme | Ovis aries |
| D714R | insensitive to palytoxin | Ovis aries |
| K691A | insensitive to palytoxin | Ovis aries |
| K691D | insensitive to palytoxin | Ovis aries |
| K691R | the EC50 of the palytoxin-induced K+ efflux is 7fold higher than in cells expressing the wild-type enzyme | Ovis aries |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| palytoxin | - |
Ovis aries |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Ovis aries | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Ovis aries | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 120 | - |
mutant K691A | Ovis aries |
| 175 | - |
mutant D714A | Ovis aries |
| 195 | - |
mutant K691R | Ovis aries |
| 575 | - |
mutant D714E | Ovis aries |
| 1105 | - |
wild-type | Ovis aries |
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