Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
vesicle | - |
Mus musculus | 31982 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Zn2+[side 1] | Mus musculus | - |
ADP + phosphate + Zn2+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HC-11 cell | - |
Mus musculus | - |
mammary gland | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Zn2+[side 1] | - |
Mus musculus | ADP + phosphate + Zn2+[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
zinc transporter 2 | - |
Mus musculus |
ZnT2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deletion is associated with cytoplasmic Zn2+ accumulation, loss of secretory function and lactation failure. Enzyme deletion results in Zn2+-mediated degradation of phosphatase and tensin homolog, which impairs intercellular junction formation, prolactin receptor trafficking, and alveolar lumen development | Mus musculus |
physiological function | the enzyme is critical for appropriate mammary gland architecture. The interaction of the enzyme with V-ATPase critically mediates polarity establishment, alveolar development, and secretory function in the lactating mammary gland. The enzyme is required for the formation of acidified vesicles and secretion in mammary epithelial cells | Mus musculus |