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Literature summary for 7.2.2.12 extracted from

  • Lee, S.; Rivera, O.; Kelleher, S.
    Zinc transporter 2 interacts with vacuolar ATPase and is required for polarization, vesicle acidification, and secretion in mammary epithelial cells (2017), J. Biol. Chem., 292, 21598-21613 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
vesicle
-
Mus musculus 31982
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+[side 1] Mus musculus
-
ADP + phosphate + Zn2+[side 2]
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HC-11 cell
-
Mus musculus
-
mammary gland
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+[side 1]
-
Mus musculus ADP + phosphate + Zn2+[side 2]
-
?

Synonyms

Synonyms Comment Organism
zinc transporter 2
-
Mus musculus
ZnT2
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deletion is associated with cytoplasmic Zn2+ accumulation, loss of secretory function and lactation failure. Enzyme deletion results in Zn2+-mediated degradation of phosphatase and tensin homolog, which impairs intercellular junction formation, prolactin receptor trafficking, and alveolar lumen development Mus musculus
physiological function the enzyme is critical for appropriate mammary gland architecture. The interaction of the enzyme with V-ATPase critically mediates polarity establishment, alveolar development, and secretory function in the lactating mammary gland. The enzyme is required for the formation of acidified vesicles and secretion in mammary epithelial cells Mus musculus