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Literature summary for 7.2.2.12 extracted from

  • Mishra, S.; Mishra, A.; Küpper, H.
    Protein biochemistry and expression regulation of cadmium/zinc pumping ATPases in the hyperaccumulator plants Arabidopsis halleri and Noccaea caerulescens (2017), Front. Plant Sci., 8, 835 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.12

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Noccaea caerulescens 5886
-
plasma membrane
-
 Arabidopsis halleri 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ isoform HMA4 reaches maximal ATPase activity when all internal high-affinity Cd2+ binding sites are occupied Noccaea caerulescens
Cd2+ isoform HMA4 reaches maximal ATPase activity when all internal high-affinity Cd2+ binding sites are occupied Arabidopsis halleri

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000 70000 gel filtration Noccaea caerulescens
60000 70000 gel filtration Arabidopsis halleri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cd2+[side 1] Noccaea caerulescens
-
 ADP + phosphate + Cd2+[side 2]
-
 ?
ATP + H2O + Cd2+[side 1] Arabidopsis halleri
-
 ADP + phosphate + Cd2+[side 2]
-
 ?
ATP + H2O + Zn2+[side 1] Noccaea caerulescens
-
 ADP + phosphate + Zn2+[side 2]
-
 ?
ATP + H2O + Zn2+[side 1] Arabidopsis halleri
-
 ADP + phosphate + Zn2+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis halleri
-
 formerly called Cardaminopsis halleri
-
Noccaea caerulescens
-
 ecotype Ganges, formerly called Thlaspi caerulescens
-

Purification (Commentary)

Purification (Comment) Organism
Zn2+ affinity column chromatography Noccaea caerulescens
Zn2+ affinity column chromatography Arabidopsis halleri

Source Tissue

Source Tissue Comment Organism Textmining
bundle sheath
-
 Noccaea caerulescens
-
leaf vein
-
 Noccaea caerulescens
-
mesophyll
-
 Arabidopsis halleri
-
root
-
 Noccaea caerulescens
-
root
-
 Arabidopsis halleri
-
shoot
-
 Noccaea caerulescens
-
shoot
-
 Arabidopsis halleri
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cd2+[side 1]
-
 Noccaea caerulescens ADP + phosphate + Cd2+[side 2]
-
 ?
ATP + H2O + Cd2+[side 1]
-
 Arabidopsis halleri ADP + phosphate + Cd2+[side 2]
-
 ?
ATP + H2O + Zn2+[side 1]
-
 Noccaea caerulescens ADP + phosphate + Zn2+[side 2]
-
 ?
ATP + H2O + Zn2+[side 1]
-
 Arabidopsis halleri ADP + phosphate + Zn2+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
Cd/Zn transporting ATPase
-
 Noccaea caerulescens
Cd/Zn transporting ATPase
-
 Arabidopsis halleri
HMA4 isoform Noccaea caerulescens
HMA4 isoform Arabidopsis halleri

Expression

Organism Comment Expression
Noccaea caerulescens in roots, isoform HMA4 is up-regulated in response to deficient Zn2+. In roots the isoform HMA4 expression is enhanced only in excess of metal (either Cd2+ orZn2+) up
Arabidopsis halleri in roots, isoform HMA4 is up-regulated in response to deficient Zn2+. In roots the isoform HMA4 expression is enhanced only in excess of metal (either Cd2+ orZn2+) up

General Information

General Information Comment Organism
physiological function isoform HMA4 is mainly responsible for xylem loading of heavy metals for root to shoot transport Noccaea caerulescens
physiological function isoform HMA4 is mainly responsible for xylem loading of heavy metals for root to shoot transport Arabidopsis halleri