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Literature summary for 7.2.2.12 extracted from

  • Kim, Y.Y.; Choi, H.; Segami, S.; Cho, H.T.; Martinoia, E.; Maeshima, M.; Lee, Y.
    AtHMA1 contributes to the detoxification of excess Zn(II) in Arabidopsis (2009), Plant J., 58, 737-753.
    View publication on PubMed
Search for more literature for 7.2.2.12

Cloned(Commentary)

Cloned (Comment) Organism
HMA1 DNA and amino acid sequence determination and analysis, phylogenetic analysis, quantitative realtime RT-PCR expression analysis, expression in Saccharomyces cerevisiae Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information sensitivity of Saccharomyces cerevisiae to high concentrations of Zn2+ is altered by the expression of AtHMA1 lacking its N-terminal chloroplast-targeting signal. Construction of HMA knockout plants showing as more pronounced sensitivity in the presence of high Zn2+ concentrations, and increased accumulation of Zn in the chloroplast of T-DNA insertional mutants of AtHMA1 compared to the wild-type, overview. The Zn2+-sensitive phenotype of AtHMA1 knock-out plants is complemented by the expression of AtHMA1 under the control of its own promoter. No organ-specific differences in the Zn content of hma1-1 mutants Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast envelope
-
 Arabidopsis thaliana 9941
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+/in Arabidopsis thaliana AtHMA1 contributes to the detoxification of excess Zn(II) in Arabidopsis thaliana by reducing the Zn content of Arabidopsis thaliana plastids, regulation, overview ADP + phosphate + Zn2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
 Arabidopsis thaliana
-
leaf rosette leaves and cauline leaves Arabidopsis thaliana
-
additional information expression pattern of HMA1 invarious tissues of wild-type plants, HMA1 is expressed preferentially in shoots, including rosette leaves, cauline leaves, ?owers and stems, but little expression is observed in the roots, overview Arabidopsis thaliana
-
shoot HMA1 is expressed preferentially in shoots Arabidopsis thaliana
-
stem
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+/in
-
 Arabidopsis thaliana ADP + phosphate + Zn2+/out
-
 ?
ATP + H2O + Zn2+/in AtHMA1 contributes to the detoxification of excess Zn(II) in Arabidopsis thaliana by reducing the Zn content of Arabidopsis thaliana plastids, regulation, overview Arabidopsis thaliana ADP + phosphate + Zn2+/out
-
 ?

Subunits

Subunits Comment Organism
More HMA1 contains poly-His motifs that are commonly found in Zn(II)-binding proteins, but lacks some amino acids that are typical for this class of transporters Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
HMA1
-
 Arabidopsis thaliana
More HMA1 is a member of the heavy metal-transporting ATPase family Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Arabidopsis thaliana