Literature summary for 7.2.2.12 extracted from

Hussain, D.; Haydon, M.J.; Wang, Y.; Wong, E.; Sherson, S.M.; Young, J.; Camakaris, J.; Harper, J.F.; Cobbett, C.S.
P-type ATPase heavy metal transporters with roles in essential zinc homeostasis in Arabidopsis (2004), Plant Cell, 16, 1327-1339.

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Cloned(Commentary)

Cloned (Comment)	Organism
identification of two independent mutant alleles for both genes, HMA2 and HMA4. The hma2-2 mutant is indistinguishable from the wild-type, whereas the hma4-1 and the double mutant hma2-2,hma4-1 accumulate approximately 2fold and 4fold less Zn, respectively, than the wild type.	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	HMA2	Arabidopsis thaliana	5886	-

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + H2O + Zn2+[side 1] = ADP + phosphate + Zn2+[side 2]	HMA2 and HMA4 play essential roles in the homeostasis of Zn.	Arabidopsis thaliana	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Arabidopsis thaliana	-
root	-	Arabidopsis thaliana	-
stem	-	Arabidopsis thaliana	-

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Release 2023.1 (January 2023)