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Literature summary for 7.2.2.10 extracted from

  • Peters, A.; Milevskiy, M.; Lee, W.; Curry, M.; Smart, C.; Saunus, J.; Reid, L.; Da Silva, L.; Marcial, D.; Dray, E.; Brown, M.; Lakhani, S.; Roberts-Thomson, S.; Monteith, G.
    The calcium pump plasma membrane Ca2+-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin (2016), Sci. Rep., 6, 25505 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine plasmalemmal Ca2+ pump isoform 2 mRNA levels are a potential tool in identifying poor responders to therapy in women with basal breast cancer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+[side 1] Homo sapiens
-
ADP + phosphate + Ca2+[side 2]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+[side 1]
-
Homo sapiens ADP + phosphate + Ca2+[side 2]
-
?

Synonyms

Synonyms Comment Organism
plasma membrane Ca2+-ATPase 2
-
Homo sapiens
plasmalemmal Ca2+ pump isoform 2
-
Homo sapiens
PMCA2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens PMCA2 mRNA levels are enriched in basal breast cancer cells up

General Information

General Information Comment Organism
malfunction silencing of isoform PMCA2 reduces MDA-MB-231 breast cancer cell proliferation, whereas silencing of the related isoforms PMCA1 and PMCA4 has no effect. PMCA2 silencing also sensitizes MDA-MB-231 cells to doxorubicin Homo sapiens
physiological function plasma membrane Ca2+-ATPase 2 regulates breast cancer cell proliferation and sensitivity to doxorubicin Homo sapiens