Application | Comment | Organism |
---|---|---|
medicine | plasmalemmal Ca2+ pump isoform 2 mRNA levels are a potential tool in identifying poor responders to therapy in women with basal breast cancer | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Ca2+[side 1] | Homo sapiens | - |
ADP + phosphate + Ca2+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Ca2+[side 1] | - |
Homo sapiens | ADP + phosphate + Ca2+[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
plasma membrane Ca2+-ATPase 2 | - |
Homo sapiens |
plasmalemmal Ca2+ pump isoform 2 | - |
Homo sapiens |
PMCA2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | PMCA2 mRNA levels are enriched in basal breast cancer cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing of isoform PMCA2 reduces MDA-MB-231 breast cancer cell proliferation, whereas silencing of the related isoforms PMCA1 and PMCA4 has no effect. PMCA2 silencing also sensitizes MDA-MB-231 cells to doxorubicin | Homo sapiens |
physiological function | plasma membrane Ca2+-ATPase 2 regulates breast cancer cell proliferation and sensitivity to doxorubicin | Homo sapiens |