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Literature summary for 7.2.2.10 extracted from
- E2P-like states of plasma membrane Ca2+-ATPase characterization of vanadate and fluoride-stabilized phosphoenzyme analogues (2019), Biochim. Biophys. Acta Biomembr., 1861, 366-379 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aluminium fluoride | the inhibition by aluminium fluoride is dependend on Mg2+ concentration | Homo sapiens |  |
| beryllium fluoride | the inhibition by beryllium fluoride is dependend on Mg2+ concentration | Homo sapiens | |
| magnesium fluoride | the inhibition by magnesium fluoride is dependend on Mg2+ concentration | Homo sapiens | |
| Sodium fluoride | the inhibition by magnesium fluoride is dependend on Mg2+ concentration. The enzyme is totally inhibited by NaF at total Mg2+ concentrations higher than 3.5 mM | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 0.1 mM used in assay conditions | Homo sapiens | |
| K+ | 120 mM used in assay conditions | Homo sapiens | |
| Mg2+ | 4 mM used in assay conditions | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+[side 1] | Homo sapiens | - |
ADP + phosphate + Ca2+[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+[side 1] | - |
Homo sapiens | ADP + phosphate + Ca2+[side 2] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| plasma membrane Ca2+-ATPase | - |
Homo sapiens |
| PMCA4 | isoform | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0012 | - |
aluminium fluoride | in the presence of 4 mM Mg2+, at pH 7.2 and 37°C | Homo sapiens | |
| 0.00314 | - |
Sodium fluoride | in the presence of 4 mM Mg2+, at pH 7.2 and 37°C | Homo sapiens | |
| 0.00382 | - |
beryllium fluoride | in the presence of 4 mM Mg2+, at pH 7.2 and 37°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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