Literature summary for 7.2.2.10 extracted from

Wang, X.; Li, Y.; Xie, K.; Yi, Q.; Chen, Q.; Wang, X.; Shen, H.; Xia, Q.; Zhao, P.
Ca2+ and endoplasmic reticulum Ca2+-ATPase regulate the formation of silk fibers with favorable mechanical properties (2015), J. Insect Physiol., 73, 53-59.

Search for more literature for 7.2.2.10

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Bombyx mori

Inhibitors

Inhibitors	Comment	Organism	Structure
thapsigargin	-	Bombyx mori

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
sarcoplasmic reticulum	-	Bombyx mori	16529	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	Bombyx mori	-	ADP + phosphate + Ca2+[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Bombyx mori	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
silk gland	-	Bombyx mori	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	-	Bombyx mori	ADP + phosphate + Ca2+[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
sarcoplasmic reticulum Ca2+-ATPase	-	Bombyx mori
SERCA	-	Bombyx mori

General Information

General Information	Comment	Organism
malfunction	after injection of thapsigargin to block enzyme activity, silkworms show a silk-spinning deficiency (30% of silkworms cannot spin normally and another 25% constructes abnormal cocoons) and their cocoons have higher calcium content compared to that of controls	Bombyx mori
physiological function	the enzyme has a key function in calcium transportation in anterior silk gland that is related to maintaining a suitable ionic environment. This ionic environment with a proper Ca2+ concentration is crucial for the formation of silk fibers with favorable mechanical performances	Bombyx mori

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Release 2023.1 (January 2023)