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Literature summary for 7.2.2.10 extracted from

  • Afroze, T.; Yang, G.; Khoshbin, A.; Tanwir, M.; Tabish, T.; Momen, A.; Husain, M.
    Calcium efflux activity of plasma membrane Ca2+ ATPase-4 (PMCA4) mediates cell cycle progression in vascular smooth muscle cells (2014), J. Biol. Chem., 289, 7221-7231.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.10

Protein Variants

Protein Variants Comment Organism
additional information a splice variant PMCA4b-Asp mutant exhibits 10% of the Ca2+ efflux activity of wild type isoform PMCA4 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+[side 1] Mus musculus
-
 ADP + phosphate + Ca2+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus H2BL43
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder predominant expression of splice variant PMCA4a Mus musculus
-
brain predominant expression of splice variant PMCA4e Mus musculus
-
carotid artery
-
 Mus musculus
-
heart predominant expression of splice variant PMCA4e Mus musculus
-
kidney predominant expression of splice variant PMCA4e Mus musculus
-
additional information liver show negligible PMCA4 expression Mus musculus
-
MOVAS cell
-
 Mus musculus
-
skeletal muscle predominant expression of splice variant PMCA4e Mus musculus
-
stomach predominant expression of splice variant PMCA4e Mus musculus
-
uterus predominant expression of splice variant PMCA4e Mus musculus
-
vascular smooth muscle cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+[side 1]
-
 Mus musculus ADP + phosphate + Ca2+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
plasma membrane Ca2+-ATPase-4
-
 Mus musculus
PMCA4
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus splice varianta PMCA4e and PMCA4a show higher expression level in injured carotids compared to uninjured carotids up