Literature summary for 7.2.2.10 extracted from

Chen, Q.; Mahendrasingam, S.; Tickle, J.A.; Hackney, C.M.; Furness, D.N.; Fettiplace, R.
The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells (2012), Eur. J. Neurosci., 36, 2302-2310.

Search for more literature for 7.2.2.10

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Rattus norvegicus	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	Rattus norvegicus	-	ADP + phosphate + Ca2+[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cochlear hair cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Ca2+[side 1]	-	Rattus norvegicus	ADP + phosphate + Ca2+[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
plasma membrane calcium ATPase	-	Rattus norvegicus
plasma membrane calcium ATPase 2 calcium pump	-	Rattus norvegicus
PMCA2	isoform	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	the limited ability of isoform PMCA2 to extrude the Ca2+ load through mechanotransducer channels may constitute a major cause of cochlear outer hair cell vulnerability and high-frequency hearing loss	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)