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Literature summary for 7.2.2.10 extracted from

  • Patel, R.; Al-Dossary, A.A.; Stabley, D.L.; Barone, C.; Galileo, D.S.; Strehler, E.E.; Martin-DeLeon, P.A.
    Plasma membrane Ca2+-ATPase 4 in murine epididymis: secretion of splice variants in the luminal fluid and a role in sperm maturation (2013), Biol. Reprod., 89, 6-6.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.10

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
128000
-
 x * 128000, splice variant PMCA4a, SDS-PAGE Mus musculus
133000
-
 x * 133000, splice variant PMCA4b, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+[side 1] Mus musculus
-
 ADP + phosphate + Ca2+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6Q477
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymal fluid
-
 Mus musculus
-
epididymis apical membrane of the epididymal epithelium Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+[side 1]
-
 Mus musculus ADP + phosphate + Ca2+[side 2]
-
 ?

Subunits

Subunits Comment Organism
? x * 128000, splice variant PMCA4a, SDS-PAGE Mus musculus
? x * 133000, splice variant PMCA4b, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
plasma membrane Ca2+-ATPase isoform 4
-
 Mus musculus
PMCA4a splice variant Mus musculus
PMCA4b splice variant Mus musculus

General Information

General Information Comment Organism
physiological function the combination of the functional attributes of both PMCA4 variants leads to heightened efficiency of the pump in the maintenance of Ca2+ homeostasis, which is crucial for normal motility and male fertility Mus musculus