Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | auto-inhibited Ca2+-ATPase | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclopiazonic acid | inhibitor of ER-type Ca2+-ATPases | Arabidopsis thaliana | |
eosin Y | auto-inhibited Ca2+-ATPases are particularly sensitive to inhibition by eosin Y | Arabidopsis thaliana | |
erythrosin B | auto-inhibited Ca2+-ATPases are particularly sensitive to inhibition by erythrosin B | Arabidopsis thaliana | |
La3+ | - |
Arabidopsis thaliana | |
orthovanadate | - |
Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | isoform ECA3 | Arabidopsis thaliana | 5794 | - |
membrane | - |
Arabidopsis thaliana | 16020 | - |
plasma membrane | isoform ACA9 | Arabidopsis thaliana | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Arabidopsis thaliana | |
Mn2+ | ER-type Ca2+-ATPases can transport, beside Ca2+, also Mn2+ and Zn2+ ions | Arabidopsis thaliana | |
Zn2+ | ER-type Ca2+-ATPases can transport, beside Ca2+, also Mn2+ and Zn2+ ions | Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | auto-inhibited Ca2+-ATPase | Arabidopsis thaliana |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pollen | isoform ACA9 | Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Ca2+/out | - |
Arabidopsis thaliana | ADP + phosphate + Ca2+/in | - |
? | |
additional information | ER-type Ca2+-ATPases show a strong preference for ATP as substrate. Conversely, auto-inhibited Ca2+-ATPases are able to use ITP or GTP as an alternative to ATP | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACA | - |
Arabidopsis thaliana |
auto-inhibited Ca2+-ATPase | - |
Arabidopsis thaliana |
Ca2+-ATPase | - |
Arabidopsis thaliana |
Ca2+-pumping ATPase | - |
Arabidopsis thaliana |
eCA | - |
Arabidopsis thaliana |
ER-type Ca2+-ATPase | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
malfunction | knock-out mutants of isoform ACA9 displays reduced growth of pollen tubes, with high frequency of aborted fertilization leading to a 3fold reduction in seed set. Knock-out mutants of isoforms ACA8 or ACA10 do not have an altered phenotype, with a noticeable exception: knock-out of ACA10 in a genotype containing a naturally occurring dominant allele of an unlinked gene causes altered adult vegetative development and the formation of floral clusters. Isoform ECA1 knock-out mutant is indistinguishable from the wild type, but it clearly shows reduced root growth and toxicity symptoms when exposed to 0.5 mM Mn2+. An ECA3 knock-out mutant is not more sensitive than the wild type to Mn2+ toxicity, but rather requires higher Mn2+ concentrations for growth. Both isoform ECA1 and ECA3 knock-out mutants have slightly altered Ca2+ sensitivity | Arabidopsis thaliana |
physiological function | Ca2+-ATPases use the energy of ATP hydrolysis to pump Ca2+ from the cytoplasm into intracellular compartments or into the apoplast. Ca2+-ATPases play an important role in maintenance of cytoplasmic Ca2+ homeostasis. Isoform ECA3 may also play an essential role in Mn2+ nutrition. Plasma membrane-localized auto-inhibited Ca2+-ATPases are also involved in the response to pathogens, hormonal regulation, salt stress, and cold stress | Arabidopsis thaliana |