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Literature summary for 7.2.2.10 extracted from
- Tetrabromobisphenol A (TBBPA), induces cell death in TM4 Sertoli cells by modulating Ca2+ transport proteins and causing dysregulation of Ca2+ homeostasis (2008), Toxicol. In Vitro, 22, 943-952.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| orthovanadate | the Ca2+ pump is inhibited by orthovanadate (0.1 mM) once sufficient Ca2+ accumulation has occurred | Mus musculus | |
| tetrabromobisphenol A | can inhibit SERCA at low concentrations (IC50, 0.0004-0.0012 mM) | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| sarcoplasmic reticulum | - |
Mus musculus | 16529 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Sertoli cell | - |
Mus musculus | - |
| TM-4 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Ca2+/cis | - |
Mus musculus | ADP + phosphate + Ca2+/trans | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sarcoplasmic/endoplasmic reticulum Ca2+-ATPase | - |
Mus musculus |
| SERCA | - |
Mus musculus |
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Release 2023.1 (January 2023)
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