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Literature summary for 7.2.2.10 extracted from

  • Wu, X.; Chang, B.; Blair, N.S.; Sargent, M.; York, A.J.; Robbins, J.; Shull, G.E.; Molkentin, J.D.
    Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents (2009), J. Clin. Invest., 119, 976-985.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.10

Application

Application Comment Organism
medicine PMCA4b overexpression significantly reduces cardiac hypertrophy following pressure overload Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ PMCA extrudes Ca2+ but has little effect on excitation-contraction coupling, Pmca4b likely reduces the local Ca2+ signals involved in reactive cardiomyocyte hypertrophy via calcineurin regulation Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
plasma membrane Ca2+-ATPase
-
 Mus musculus
PMCA4b isoform Mus musculus