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Literature summary for 7.2.2.10 extracted from

  • Deye, J.; Elam, C.; Lape, M.; Ratliff, R.; Evans, K.; Paula, S.
    Structure-based virtual screening for novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase and their experimental evaluation (2009), Bioorg. Med. Chem., 17, 1353-1360.
    View publication on PubMed
Search for more literature for 7.2.2.10

Inhibitors

Inhibitors Comment Organism Structure
1,1'-methanediyldinaphthalen-2-ol
-
 Oryctolagus cuniculus
1-(naphthalen-1-ylmethyl)naphthalen-2-ol
-
 Oryctolagus cuniculus
2,2',2''-methanetriyltris(4-tert-butylphenol)
-
 Oryctolagus cuniculus
2,2'-methanediylbis(4-tert-butylphenol)
-
 Oryctolagus cuniculus
2,4-di-tert-butyl-6-(1-phenylethyl)phenol
-
 Oryctolagus cuniculus
2,4-di-tert-butyl-6-[1-(4-methoxyphenyl)ethyl]phenol
-
 Oryctolagus cuniculus
2,5-bis(2-methylpropyl)phenol
-
 Oryctolagus cuniculus
2,5-bis(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol
-
 Oryctolagus cuniculus
2,6-di-tert-butyl-4-[1-(4-methoxyphenyl)ethyl]phenol
-
 Oryctolagus cuniculus
2-(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol
-
 Oryctolagus cuniculus
2-cyclooctylbenzene-1,4-diol
-
 Oryctolagus cuniculus
3-(1,1-diphenylethyl)cyclopentanol
-
 Oryctolagus cuniculus
4,4'-butane-2,2-diylbis(2-methylphenol)
-
 Oryctolagus cuniculus
4,4'-butane-2,3-diyldiphenol
-
 Oryctolagus cuniculus
4,4'-propane-2,2-diylbis(2,6-dimethylphenol)
-
 Oryctolagus cuniculus
4,5-dibenzylbenzene-1,2-diol
-
 Oryctolagus cuniculus
4-(7-methyloctyl)phenol
-
 Oryctolagus cuniculus
6-tert-butyl-2,3-dihydro-1H-inden-5-ol
-
 Oryctolagus cuniculus
biphenyl-2,5-diol
-
 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Oryctolagus cuniculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P04191
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/cis
-
 Oryctolagus cuniculus ADP + phosphate + Ca2+/trans
-
 ?

Synonyms

Synonyms Comment Organism
sarco/endoplasmic reticulum calcium ATPase
-
 Oryctolagus cuniculus
SERCA
-
 Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00229
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus biphenyl-2,5-diol
0.0094
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2,5-bis(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol
0.0115
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2-cyclooctylbenzene-1,4-diol
0.0118
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2,2'-methanediylbis(4-tert-butylphenol)
0.015
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 1,1'-methanediyldinaphthalen-2-ol
0.0172
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 4-(7-methyloctyl)phenol
0.0188
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2,5-bis(2-methylpropyl)phenol
0.0195
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 4,4'-propane-2,2-diylbis(2,6-dimethylphenol)
0.0202
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2-(cyclopenta-2,4-dien-1-ylmethyl)benzene-1,4-diol
0.0213
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2,2',2''-methanetriyltris(4-tert-butylphenol)
0.0238
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 4,5-dibenzylbenzene-1,2-diol
0.0273
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 1-(naphthalen-1-ylmethyl)naphthalen-2-ol
0.0281
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 6-tert-butyl-2,3-dihydro-1H-inden-5-ol
0.0283
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 4,4'-butane-2,3-diyldiphenol
0.0338
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2,4-di-tert-butyl-6-(1-phenylethyl)phenol
0.0353
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2,4-di-tert-butyl-6-[1-(4-methoxyphenyl)ethyl]phenol
0.0393
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 4,4'-butane-2,2-diylbis(2-methylphenol)
0.0454
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 2,6-di-tert-butyl-4-[1-(4-methoxyphenyl)ethyl]phenol
0.0497
-
 In 0.1 M KCl, 5 mM MgCl2, 0.5 mM EGTA, 0.004.5 mM calcimycin, 0.7 mM CaCl2, and 20 mM Trizma (pH 7.5) Oryctolagus cuniculus 3-(1,1-diphenylethyl)cyclopentanol